Approved Abstracts

MICROPLASTIC INDUCED ANTIOXIDANT SYSTEM CHANGES IN LIVER AND KIDNEY: RELATIONSHIP TO DIET



Author(s): Batista R.; Peixoto F.; Oliveira MM;
Presenter: Maria Manuel Oliveira

In the modern world, the reliance on plastic polymers to produce consumer products is unavoidable, mainly due to the reduced manufacturing costs of lightweight and durable products. This fact is evident in the production of essential goods such as clothing, cosmetics and high-tech products. Even in the medical field, plastic products play a crucial role as aseptic and disposable tools that guarantee the highest level of hygiene. Therefore, the importance of plastic for today‘s consumers is unquestionable. However, post-use plastic conflicts begin to haunt human civilization and threaten the balance of the ecosystem.
Microplastics, which have sizes smaller than 5 mm, are ubiquitous in the environment. They are divided into primary and secondary. The primary is those released directly into the environment as small particles. Secondary ones originate from the degradation of larger plastics, such as garbage bags or bottles.
This work aimed to evaluate the impact of microplastics ingestion in the enzymatic antioxidant system of liver and kidney, in rats with normal and hypercaloric diets.
Twelve mice were divided in four groups, the control one with normal diet and no microplastics (CTR), the hypercaloric diet group (HD), the microplastics group with normal diet (MP) and the microplastics group with hypercaloric diet (MP+HD). The animals were subject to these diets for 28 days. After this period, they were sacrificed and the organs removed to carry out the different analyses.
In the liver, catalase and superoxide dismutase activities are significantly increased in both microplastics groups (MP and MP+HD). Glutathione reductase activity is increased in all groups relative to the control, but this effect is more significant in the hypercaloric diet groups. The glutathione-S-transferase activity is decreased in all groups compared to control but is only significant in the MP group. The results obtained for the kidney will be presented as well as all other oxidative stress biomarkers understudy like carbonyls and lipid oxidation, thiols content and oxidative stress index, among others.


Keywords: microplastics; hypercaloric diet; oxidative stress biomarkers

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